George D Synder

Overcoming HPV George D Synder

The human papillomavirus (HPV) ?? a sexually transmitted ?nf??t??n ??mm?n ?m?ng m?n ?nd w?m?n across all g??gr??h?? ?nd ★★★★★★??n?m?? subgroups w?rldw?d?. Recent evidence ?ugg??t? th?t HPV ?nf??t??n may ?ff??t fertility and ?lt?r th? ?ff????? of assisted r??r?du?t?v? technologies. In men, HPV ?nf??t??n ??n ?ff??t ???rm ??r?m?t?r?, specifically motility. HPV-?nf??t?d ???rm ??n transmit viral DNA t? ????t??, wh??h m?? b? ?x?r????d ?n the d?v?l???ng blastocyst. HPV ??n ?n?r???? tr??h?bl??t?? ????t???? ?nd reduce the ?nd?m?tr??l ?m?l?nt?t??n ?f tr??h?bl??t?? ??ll?, thu? increasing the theoretical risk ?f m????rr??g?. V?rt???l tr?n?m?????n of HPV during ?r?gn?n?? m?? be ?nv?lv?d ?n the pathophysiology ?f ?r?t?rm ru?tur? of m?mbr?n?? and ???nt?n??u? preterm birth. In ??t??nt? und?rg??ng ?ntr?ut?r?n? insemination f?r ?d????th?? infertility, HPV ?nf??t??n confers a l?w?r pregnancy r?t?. In contrast, the ?v?d?n?? r?g?rd?ng ?n? d?tr?m?nt?l ?m???t of HPV ?nf??t??n ?n IVF ?ut??m?? is ?n??n?lu??v?. It h?? been ?ugg??t?d th?t vaccination ??uld ??t?nt??ll? ??unt?r HPV-related sperm impairment, trophoblastic apoptosis, ?nd ???nt?n??u? m????rr??g??; h?w?v?r, th??? ??n?lu???n? ?r? based on ?n v?tr? ?tud??? r?th?r th?n l?rg?-???l? ???d?m??l?g???l ?tud???. Improvement ?n th? und?r?t?nd?ng ?f HPV ???rm infection mechanisms ?nd HPV transmission into th? ????t? ?nd d?v?l???ng bl??t????t m?? h?l? ?x?l??n ?d????th?? ??u??? of ?nf?rt?l?t? and m????rr??g?.