Vasiliy Akhunov

Osobennosti Bronkhial'noy Astmy Pri Petsilomikoze Vasiliy Akhunov Russian edition

Nesmotrya na uspekhi v ponimanii patogeneza i vozmozhnosti sovremennoy farmakoterapii otmechaetsya postoyannyy i neuklonnyy rost chislennosti bol'nykh bronkhial'noy astmoy (BA). V nastoyashchee vremya BA nezavisimo ot stepeni tyazhesti schitaetsya khronicheskim vospalitel'nym zabolevaniem dykhatel'nykh putey, etiologicheskiy faktor kotorogo neizvesten. Dannyy tip vospaleniya tesno vzaimosvyazan s bronkhial'noy giperreaktivnost'yu, khotya mekhanizm etoy vzaimosvyazi na nastoyashchiy moment polnost'yu ne raskryt. Vozmozhnosti sovremennoy farmakoterapii kontroliruemoy s pomoshch'yu glyukokortikosteroidov (GKS) pozvolyayut dobit'sya v bol'shinstve sluchaev stoykoy remissii. Odnako, stupenchatyy podkhod k naznacheniyu ingalyatsionnykh GKS ( GINA, 2007) trebuet primeneniya v ryade sluchaev dostatochno vysokikh doz preparatov. V to zhe vremya ispol'zovanie ingalyatsionnykh GKS podavlyaet mestnyy immunitet, sposobstvuet razvitiyu steroidnoy zavisimosti i drugikh nezhelatel'nykh yavleniy. V svyazi s etim ves'ma aktual'nym yavlyaetsya vopros izucheniya osobennostey kliniko-laboratornoy diagnostiki i vozmozhnostey ispol'zovaniya sistemnykh antimikotikov v lechenii bol'nykh s bronkhial'noy astmoy.