Harapan Harapan

Microrna - Preeclampsia: from Speculation to Rationalization Harapan Harapan

Preeclampsia, ?the disease of theory?, is a major cause of maternal mortalities and morbidities, perinatal deaths, preterm birth, and intrauterine growth restriction. Several pathophysiological mechanisms have been proposed in pathogenesis of preeclampsia, including endothelial dysfunction, an inflammatory pathway, oxidative stress, activation of thrombosis, the renin-angiotensin system and angiogenic factors. However, the individual theory cannot explain clinical features of preeclampsia holistically. The discovery of MicroRNA in 1993 has had a huge influence in pathogenesis theory; diagnosis and treatment approach to some diseases. Albeit only 1% of the genomic transcripts, it has been estimated that MicroRNAs regulate ~30% of human genes. This book discusses the roles of MicroRNAs in several pathophysiological mechanisms that have been proposed in the development of preeclampsia in advance setting. This book, clearly, shows the role of MicroRNA as a new aspect in pathobiology of preeclampsia thus, hopefully, this book can helps people to understanding more about preeclampsia from advance molecular stand points.