Philip R Dormitzer

Replicating Vaccines: A New Generation - Birkhauser Advances in Infectious Diseases Philip R Dormitzer 2011 edition

Marc Notes: Includes bibliographical references and index. Review Quotes: From the reviews: This book introduces the current thinking on rational attenuation and this important theme runs through the book, tying the chapters together very nicely. Given the renaissance in vaccinology this is a timely volume which makes judicious use of selected examples to highlight key aspects of this burgeoning field. This book is both a useful primer for students and a thought-provoking read for researchers in this field. (Paul Duprex, Microbiology Today, November, 2011) Table of Contents: SECTION 1: Today s Live Attenuated Vaccines.- Live Vaccines and their Role in Modern Vaccinology.- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster.- Classical Live Viral Vaccines.- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines.- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus.- Live Attenuated Shigella Vaccines. Is encouraging good enough?.- New generation BCG vaccines.- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines.- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines.- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches.- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread.- RSV Deletion Mutant Innate Immunity.- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity.- SECTION 4: New Types of Replicating Vaccines.- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors.- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines.- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines.- Alphavirus Particle-based Vaccine Vectors.- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses."Review Quotes: From the reviews: This book introduces the current thinking on rational attenuation and this important theme runs through the book, tying the chapters together very nicely. Given the renaissance in vaccinology this is a timely volume which makes judicious use of selected examples to highlight key aspects of this burgeoning field. This book is both a useful primer for students and a thought-provoking read for researchers in this field. (Paul Duprex, Microbiology Today, November, 2011)"