Roger D Cone

The Melanocortin Receptors - The Receptors Roger D Cone 2000 edition

Marc Notes: Includes bibliographical references and index. Review Quotes: "New data on melanocortin receptors 1-5 and their regulation are the topic of several chapters. A complete, well referenced text of interest to all endocrinologists, neuroscientists, geneticists, physiologists and pharmacologists." - Journal of Pediatric Endocrinology & MetabolismTable of Contents: Part I: Historical Perspectives. Proopiomelanocortin and the Melanocortin Peptides, A. N. Eberle. Melanocortins and Pigmentation, A. B. Lerner. Melanocortins and Adrenocortical Function, M. Begeot and J. M. Saez. Effects of Melanocortins in the Nervous System, R. A. H. Adan. Peripheral Effects of Melanocortins, B. A. Boston. Part II. Characterization of the Melanocortin Receptors. Melanocortin Receptor Expression and Function in the Nervous System, J. B. Tatro. Cloning of the Melanocortin Receptors, K. G. Mountjoy. Part III. Biochemical Mechanism of Receptor Action. The Molecular Pharmacology of Alpha-Melanocyte Stimulating Hormone: Structure-Activity Relationships for Melanotropins at Melanocortin Receptors, V. J. Hruby and G. Han. In Vitro Mutagenesis Studies of Melanocortin Receptor Coupling and Ligand Binding, C. Haskell-Luevano. Part IV. Receptor Function. The Melanocortin-1 Receptor, D. Lu, C. Haskell-Luevano, D. I. Vage, and R. D. Cone. The Human Melanocortin-1 Receptor, E. Healy, M. Birch-Machin, and J. L. Rees. The Melanocortin-2 Receptor in Normal Adrenocortical Function and Familial Adrenocorticotropic Hormone Resistance, A. J. L. Clark. The Melanocortin-3 Receptor, R. A. Kesterson. The Melanocortin-4 Receptor, R. D. Cone. The Melanocortin-5 Receptor, W. Chen. Part V. Receptor Regulation. Regulation of the Melanocortin Receptors by Agouti, W. O. Wilkison. Melanocortins and Melanoma, A. N. Eberle, S. Froidevaux, and W. Siegrist. Regulation of the Mouse and Human Melanocortin-1 Receptor, Z. Abdel-Malek. Part VI. Future Vistas. Future Vistas. R. D. Cone. Index."Publisher Marketing: The cutting-edge reviews assembled in this book cover the entire biology of the melanocortin peptide system, especially the melanocrotin receptors. Among the receptors surveyed are the MC1, MC1-R, MC2-R, MC3-R, MC5-R and MC4 which is now a drug target for the treatment of obesity. This book explains how the melanocortin peptides work together to provide a fine-tuned control over physiological processes as diverse as energy, homeostasis, pigmentation, steroidogenesis and exocrine gland function.