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Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique D.m. Patel
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Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique
D.m. Patel
Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.
| Mediji | Grāmatas Paperback Book (Grāmata ar mīksto vāku un līmēto muguru) |
| Izlaists | 2014. gada 13. februāris |
| ISBN13 | 9783846504055 |
| Izdevēji | LAP LAMBERT Academic Publishing |
| Lapas | 124 |
| Izmēri | 150 × 7 × 226 mm · 190 g |
| Valoda | Angļu |
Skatīt visus D.m. Patel ( piem., Paperback Book )