Paulson Mathew

Novel Methods for Pyrrole Synthesis: Application in Total Synthesis of Marine Natural Products Paulson Mathew

Functionalized pyrroles belong to an extremely attractive domain in heterocyclic chemistry as a result of their diverse bioactivities and its incorporation in various natural products, including porphyrins. The book addresses development of novel approaches for the synthesis of substituted pyrroles and their applications in the total synthesis of marine anticancer agents like lamellarin O, lamellarin Q, lukianol A and rigidin. Major part of the work illustrates the syntheses of ketene-N, S-acetals and its transformation to functionalised pyrroles. The book illustrates methods for the partial or complete sulfhydrolysis of dithioacetals to thiol esters or aldehydes respectively. A full review on methods for pyrrole synthesis has been made and included as a separate chapter. Appropriate literature reviews and original spectra, and detailed experimental procedures are included under main titles for originality and thoroughness. The book will definitely help advanced undergraduate students as well as doctoral students in organising their project work. The book can help the industry people who are engaged in developing anticancer agents.