Mikhail Rubtsov

Vtorichnye Leykozy: Gipotezy Vozniknoveniya: Relokalizatsiya Protoonkogenov I Rol' Yadryshka Mikhail Rubtsov Russian edition

Leykemii sostavlyayut 3% ot obshchego chisla onkologicheskikh zabolevaniy v mire. Razvitie ostroy mieloidnoy leykemii (AML) obychno svyazyvayut s khromosomnymi perestroykami, privodyashchimi k obrazovaniyu khimernykh genov. Translokatsiya t(8;21)(q22;q22), ob"edinyayushchaya geny AML1 i ETO - odna iz naibolee chastykh translokatsiy, nablyudaemykh pri AML. Ezhegodno ona diagnostiruetsya v 40% sluchaev ostroy mieloblastnoy leykemii, i soprovozhdaet do 40% sluchaev detskoy AML. No osobenno chasto eta translokatsiya nablyudaetsya pri tak nazyvaemykh «obuslovlennykh lecheniem» (treatment related) ili vtorichnykh leykozakh, voznikayushchikh vsledstvie khimioterapii «pervichnykh» opukholey, provodyashcheysya s ispol'zovaniem preparatov, spetsificheski ingibiruyushchikh DNK-topoizomerazu II i vyzyvayushchikh gibel' aktivno delyashchikhsya kletok. V dannoy rabote vpervye issledovano vzaimnoe raspolozhenie genov AML1 i ETO v trekhmernom prostranstve yadra kletki v norme i v usloviyakh, imitiruyushchikh khimioterapiyu. Pokazana ikh relokalizatsiya s uchastiem yadernogo miozina, polucheny ukazaniya na sushchestvovanie ranee neizvestnykh nekanonicheskikh funktsiy yadryshka. Kniga budet interesna molekulyarnym biologam, genetikam, biokhimikam, medikam.