Kafil Akhtar

Cytology of Cancer: Cervix Postradiation Kafil Akhtar

The book entails the incidence of cancer cervix, it's clinical features and the utility of cytological investigation in the form of Papanicolaou smears in the diagnosis of the disease. Cytology has been known to play a major role in evaluating patients after radiotherapy. The highlight of the book is the engrossing description of the various cytological changes due to radiation therapy and how these cytological changes which are characterized by four distinct cellular changes namely, vacuolization of the cytoplasm, enlargement of the cell, wrinkling of the nucleus with disarrangement of the chromatin pattern and an increase in the number of nuclei per cell, help in the diagnosis and prognosis of stage of the disease. The study also throws light on the significance of post radiation cytological changes in detecting recurrence of carcinoma and residual disease. There has been a growing interest in the study of DNA and proliferation markers. A special study on AgNOR count in cancer cervix , which is an important index for assessment of proliferating cells is also emphasized in this book.