Mathematical Modelling of Chromosome Replication and Replicative Stress - Springer Theses - Jens Karschau - Grāmatas - Springer International Publishing AG - 9783319088600 - 2014. gada 25. jūlijs
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Jens Karschau
Mathematical Modelling of Chromosome Replication and Replicative Stress - Springer Theses 2015 edition

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DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.

This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?.

A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.

89 pages, 48 black & white illustrations, 9 colour illustrations, biography

Mediji Grāmatas     Hardcover Book   (Grāmata ar cieto muguriņu un vāku)
Izlaists 2014. gada 25. jūlijs
ISBN13 9783319088600
Izdevēji Springer International Publishing AG
Lapas 76
Izmēri 155 × 235 × 6 mm   ·   312 g
Valoda Angļu  

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