Olivia Pitts

Clinical Aspects of Peroxisome Proliferator-Activated Receptors Olivia Pitts

Nuclear receptor proteins which function as transcription factors that regulate gene expression are called peroxisome proliferator-activated receptors (PPARs). These have crucial roles in the regulation of cellular metabolism, differentiation and development, as well as in tumorigenesis. There are three types of PPARs that have been identified so far- alpha (α), beta/delta (β/δ) and gamma (γ). There can be disorders of PPARs, which generally lead to a loss in function, insulin resistance, concomitant lipodystrophy and/or acanthosis nigricans. This book provides comprehensive insights into peroxisome proliferator-activated receptors. It aims to shed light on the clinical aspects of peroxisome proliferator-activated receptors and the recent researches in this domain. Coherent flow of topics, student-friendly language and extensive use of examples make this book an invaluable source of knowledge.