Warren C W Chan

Bio-Applications of Nanoparticles - Advances in Experimental Medicine and Biology Warren C W Chan Softcover reprint of hardcover 1st ed. 2007 edition

Marc Notes: This edited book highlights the central players in the bionanotechnology field - which are the nanostructures and biomolecules. It provides broad examples of current developments in bionanotechnology research and is an excellent introduction to the field. Description for Sales People: This edited book highlights the central players in the Bionanotechnology field - which are the nanostructures and biomolecules. It provides broad examples of current developments in Bionanotechnology research and is an excellent introduction to the field. The book starts by describing how nanostructures are synthesized and by describing the wide variety of nanostructures available for biological research and applications. Next, there is a focus on the assembly of nanostructures with biological molecules. In the following chapters, examples of the unique properties of nanostructures are provided along with the current applications of these nanostructures in biology and medicine. Some applications include the use of gold nanoparticles in diagnostic applications, quantum dots and silica nanoparticles for imaging, and liposomes for drug delivery. The final chapters of the book describe the toxicity of nanostructures. Table of Contents: CONTENTS Section I. Nanostructure and Biomolecule Synthesis PREFACE ........................................................................................................... vii 1. SYNTHETIC STRATEGIES TO SIZE AND SHAPE CONTROLLED NANOCRYSTALS AND NANOCRYSTAL HETEROSTRUCTURES...................................................................... 1 P. Davide Cozzoli and Liberato Manna Introduction ......................................................................................................................... 1 Colloidal Approaches: A Few General Concepts .............................................................. 3 Size Control .......................................................................................................................... 3 Shape Control ...................................................................................................................... 4 Hybrid Nanocrystals ........................................................................................................... 8 Core-Shell Nanocrystals .................................................................................................... 10 Nanocrystal Hetero-Oligomers ......................................................................................... 12 Hybrid Nanocrystals Based on Rod-Like Sections ......................................................... 14 Conclusions ........................................................................................................................ 14 2. CURRENT APPROACHES FOR ENGINEERING PROTEINS WITH DIVERSE BIOLOGICAL PROPERTIES ............................ 18 Isaac T. S. Li, Elizabeth Pham and Kevin Truong Introduction ....................................................................................................................... 18 Random Mutagenesis ........................................................................................................ 18 Site-Directed Mutagenesis ................................................................................................ 20 Non-Canonical Amino Acid Substitution ........................................................................ 21 DNA Recombination .......................................................................................................... 23 Directed Evolution ............................................................................................................. 25 Fusion Proteins .................................................................................................................. 27 Circular Permutation ........................................................................................................ 27 Conclusions and Perspectives ........................................................................................... 29 CONTENTS xvi Contents Section II. Applications of Nanostructures 3. PAST, PRESENT, AND FUTURE OF GOLD NANOPARTICLES .......................................................... 34 Travis Jennings and Geoffrey Strouse Introduction to Gold Nanoparticles ................................................................................. 34 Synthetic Routes of Materials Synthesis ......................................................................... 35 Optical and Electronic Properties .................................................................................... 37 Practical Uses of Gold Nanomaterials ............................................................................. 45 Conclusions ........................................................................................................................ 46 4. MUPublisher Marketing: This edited book highlights the central players in the Bionanotechnology field - which are the nanostructures and biomolecules. It provides broad examples of current developments in Bionanotechnology research and is an excellent introduction to the field.