Bernard Fantus

Candy Medication Bernard Fantus

This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1915. Excerpt: ... CONSTRUCTION OF FORMULAE FOR SWEET TABLETS 33 addition of sodium bicarbonate is still further useful in lessening the solubility, thereby subduing the taste. Only in the case of the bitterest alkaloids such as strychnine and of alkaloids that have to be given in large doses such as quinine are different expedients necessary. For quinine, aristochin or saloquinine solve the problem. For strychnine, Lloyd's "Alcresta" strychnine gives good results. In 1910, John Uri Lloyd9 of Cincinnati discovered that the addition of fuller's earth to alkaloids almost completely abolished their bitter taste. He found on further research that this activity resided in the finest particles, especially those of colloidal dimensions, which could be separated from the coarser portion of fuller's earth by elutriation. By means of this powder, now known as Lloyd's Reagent, it is possible to obtain the bitterest alkaloids, even strychnine, in almost tasteless form. That this strychnine combination is still active, can be proved by the fact that it will kill a dog almost as readily as the uncombined strychnine. Lloyd has coined the name "Alcresta" for these alkaloidal combinations; they are marketed by Ely Lilly and Company. The combination of the strychnine with fuller's earth is destroyed by alkali and by alcohol. Hence alcohol must not be added to the powder after the Alcresta combination has been incorporated. The addition of a little acid lessens the bitterness of the combination by lessening solubility in the mouth. The addition of acid is also of advantage to lessen the solubility in the saliva, and with it the taste, of such resinous bodies as the resin of podophyllum. Choice of Color. To indicate tablets containing poisonous substances, a dark red color is chosen, unless ca...