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Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine Lejeune, Fabrice (Institut Pasteur de Lille, 1 rue Calmette Professor, Lille, France)
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Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine
Lejeune, Fabrice (Institut Pasteur de Lille, 1 rue Calmette Professor, Lille, France)
Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD). It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine.
190 pages
| Mediji | Grāmatas Paperback Book (Grāmata ar mīksto vāku un līmēto muguru) |
| Izlaists | 2016. gada 14. marts |
| ISBN13 | 9780128044681 |
| Izdevēji | Elsevier Science Publishing Co Inc |
| Lapas | 190 |
| Izmēri | 153 × 231 × 14 mm · 317 g |
